Figure 1 drug levels in the blood with a traditional drug dosing and b controlled delivery dosing in recent years controlled drug delivery formulations and the polymers used in these systems have become much more sophisticated with the ability to do more than simply extend the effective release period for a particular drug. Polymers have played an integral role in the advancement of drug delivery technology by providing controlled release of therapeutic agents in constant doses over long periods cyclic dosage and tunable release of both hydrophilic and hydrophobic drugs from early beginnings using off the shelf . Polymers are being used extensively in drug delivery due to their surface and bulk properties they are being used in drug formulations and in drug delivery devices these drug delivery devic es may be in the form of implants for controlled drug delivery polymers used in colloidal drug. Smart polymers have enormous potential in various applications in particular smart polymeric drug delivery systems have been explored as intelligent delivery systems able to release at the appropriate time and site of action entrapped drugs in response to specific physiological triggers. Abstract targeted delivery combined with controlled drug release has a pivotal role in the future of personalized medicine this review covers the principles advantages and drawbacks of passive and active targeting based on various polymer and magnetic iron
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